Asian Journal of Research in Chemistry

  • Year: 2016
  • Volume: 9
  • Issue: 3

Synthesis and Biological Evaluation of Novel 1, 3, 4-Thiadiazole Heterocyclic Derivatives as Novel Anti-Microbial Agents

Department of Chemistry, Vikrama Simhapuri University, Nellore-524003, A.P., India

Abstract

Heterocyclic compounds are commonly used Scaffolds on which pharmacophores are arranged to provide potent and selective drugs. This is especially true for five-membered ring heterocyclic compounds, which serve as the core components of many substances that possess a wide range of interesting biological activities. New series of 1, 3, 4-Thiadiazole derivatives were synthesized From Benzyl Isocynate and Acid hydrazide, by using P-TsCl in NMP, The Novel Derivatives have been screened for their antimicrobial activity.

Keywords

1, 3, 4-Thiadiazoles, Synthesis, Anti-bacterial activity and Anti-Fungal activity