Asian Journal of Research in Pharmaceutical Science
  • Year: 2011
  • Volume: 1
  • Issue: 3

Tylophora asthmatica L. Prevents Lipid Peroxidation in Acetaminophen Induced Hepato Toxicity in Rats

  • Author:
  • R. Malathi1, S. Ahamed John2, A. Cholarajan3
  • Total Page Count: 3
  • Page Number: 71 to 73

1Department of Biotechnology, Bharathidasan University College (w), Orathanadu, Thanjavur, Tamilnadu, India

2Department of Botany, Jamal Mohamed College, Trichy, Tamilnadu, India

3Department of Microbiology, Meenakshi Chandrasekaran College of Arts and Science, Pattukkottai – 614 626, Thanjavur, Tamilnadu, India

Online published on 5 June, 2014.

Abstract

Methanolic extract of Tylophora asthmatica leaves were prepared and tested for its antilipidperoxidation effect against acetaminophen induced hepato toxicity in rats. Alteration in the levels of lipid peroxide, iron, ferritin, total cholesterol, total lipid and phospholipids were tested in both experiment and control group of rats. Acetaminophen [1gm/kg] has showed a significant increase [p<0.05] in experimental rats except the level of phospholipids, which showed a significant decrease [p<0.05] compared to control rats. Treatment with methanolic extract of Tylophora asthmatica leaves [200mg/kg] has brought back the altered levels of this parameter to the near normal levels in the dose dependent manner.

Keywords

Acetaminophen, Hepatoprotective, Tylophora asthmatica