1Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu. Andhra Pradesh, India
2Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla-522 101, (A.P), India
3Dep. of Pharmaceutics, Rahul Institute of Pharmaceutical Science and Research, Chirala-523157, (A.P.), India
4Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, India
*Corresponding Author E-mail:
Online published on 5 June, 2014.
In the present study, a series of novel Schiff bases of isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy, and elemental analysis. These compounds were screened for antioxidant activity by DPPH radical scavenging activity. In this method, the compound 3-(4-(4-dimethylaminobenzylideneamino) phenylimino) indoline-2-one (5c) showed highest antioxidant activity because of the presence of electron donating group.
Antioxidant, isatin, Schiff base
