Asian Journal of Research in Pharmaceutical Science

The diclofenac gel is prepared to treat thumb arthritis pain management. Thumb arthritis pain caused because of more friction in the base of thumb joint. The gel is semisolid dosage forms. The prepared gel is used on the skin, topical use. The affected area is applied over the diclofenac. The two gelling agent xanthan gum and cooling agent menthol were used in the development of the diclofenac sodium gel. The prepared gel formulations were estimated for drug content uniformity, viscosity, pH and stability. The drug release was quantified by in vitro diffusion through a cellulose membrane into phosphate buffer pH 6.8 at 37°C.