Asian Journal of Research in Pharmaceutical Science
  • Year: 2020
  • Volume: 10
  • Issue: 4

Formulation and Evaluation of Fast Disintegrating Tenoxicam Tablets and The Comparison with Marketed Product

  • Author:
  • Swapnil S Chopade1,*, Esther Gaikwad1, Avdhut Jadhav2, Nikhil Patil3, Santosh Payghan4
  • Total Page Count: 7
  • Published Online: Mar 9, 2021
  • Page Number: 257 to 263

1Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Panhala, Kolhapur, Maharashtra, India416114

2Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Kolhapur, Maharashtra, India416112

3Vasantidevi Patil Institute of Pharmacy, Kodoli, Panhala, Kolhapur, Maharashtra, India416114

4Principal Vasantidevi Patil Institute of Pharmacy, Kodoli, Panhala, Kolhapur, Maharashtra, India416114

*Corresponding Author E-mail: swapnilchopade.tkcp@gmail.com

Abstract

The aim of this investigation is to formulate and characterize FDTs Formulations for physicochemical properties like Differential Scanning Calorimetry (DSC) and Fourier Transformed Infra Red Spectroscopy (FTIR) characterized the interactive powder sample mixture. Rapidly disintegrating tablets were formulated by direct compression method. For disintegration time, hardness, friability, tensile strength, weight variation and in vitro release studies, the Fast disintegrating tablets have been evaluated. During the FDT process, FTIR indicated that there was no chemical reaction between the two species (drug and excipients). In all concentrations tested in the fast dissolving tablet formulation, the interactive mixture was found to be effective. In the case of interactive mixing, disintegration time (DT) of less than 30 seconds was observed. In pharmaceutical applications, FDTs can be used as a better option.

Keywords

Tenoxicam, FDTs, Direct compression method, Disintegration time, Differential Scanning Calorimetry, FTIR