1Department of Pharmaceutics, Mata Gujri College of Pharmacy, Mata Gujari University, Kishanganj, Bihar, 855107, India
2Department of Pharmacognosy, Mata Gujri College of Pharmacy, Mata Gujari University, Kishanganj, Bihar, 855107, India
3Department of Pharmaceutical Chemistry, Mata Gujri College of Pharmacy, Mata Gujari University, Kishanganj, Bihar, 855107, India
4Department of Pharmaceutical Technology, University of North Bengal, Raja Ramohanpur, Darjeeling–734013, India
*Corresponding Author E-mail: tanmayjit2016@gmail.com
Online Published on 29 January, 2024.
The majority of the active pharmaceutical components have issues with poor solubility, bioavailability, chemical stability, and moisture absorption. Pharmaceutical crystals are a reliable way to change the aforementioned physicochemical properties of drugs without changing their pharmacological behaviour. However, the success of these approaches depends on the physical and chemical properties of the molecules being developed. The development of drug products with superior physicochemical characteristics, such as melting point, tablet ability, solubility, stability, bioavailability, and permeability, while preserving the pharmacological properties of the active pharmaceutical ingredient is greatly facilitated by co-crystallization of drug substances. All the components of a cocrystal, which is a stoichiometric homogeneous multicomponent system connected by noncovalent interactions, are solid under ambient conditions.
Cocrystals, Conformer, Spray drying, Solubility, Bioavailability, Homogeneous
