Advancements in Pharmaceutical Formulations: Formulation and Evaluation of Taste-Masked Suspension of Mefenamic Acid

The present article describes formulation and evaluation of Mefenamic acid suspension. Mefenamic acid is BCS class II drugs i.e. low solubility and high permeability. Mefenamic acid suspension was formulated for pediatric patient. Major challenge is to mask a bitter taste of Mefenamic acid. The taste masking of Mefenamic acid is achieved by the matrix-based technology in drug adsorbed or entrapped in the matrix of the porous component. This may result in a delayed release of the bitter active during the transit through the oral cavity. Mefenamic acid suspensions were formulated using different concentration of Xanthan gum, Carbopol 934 P and Veegum K. The Sucrose and artificial sweetener were added to mask a bitter taste. The trials of Mefenamic acid suspension were evaluated for different parameters like macroscopy, pH, viscosity, taste evaluation, In-vitro drug release and assay. Based on the result, F 6 batch was selected for further study. The F 6 batch gives optimum viscosity, No sedimentation and phase separation. The percentage of drug release was found 100.99% at 60 minutes. The F6 formulation is sweet in taste with pleasant odour. So, based on the physical and chemical parameter of taste masked F6 formulation of mefenamic acid gives promising career for pediatric delivery.