1PhD, Riggs Pharmaceutical Department of Pharmacy, University of Karachi
2Ph.D., Head of Department PharmacologyFazaia Ruth Pfau Medical College Air College, Karachi
3Ph.D., GD Pharmaceutical Inc., OPJS University, Rajasthan
4PhD, Assistant Professor Dow University of Health Sciences, Karachi
5PhD, Department of Pathology, Dow University of Health Sciences, Karachi
*Corresponding Author E-mail: rehan_haider64@yahoo.com
Online Published on 02 March, 2026.
Cannabinoids, the living compounds in the grass, have taken substantial consideration on account of their healing potential and relating to sports use. Among the ruling class, tetrahydrocannabinol (THC) and cannabidiol (CBD) are known for their belongings on the principal central nervous system. The endocannabinoid structure (ECS) plays an important role in modulating reward, ambition, and stress answers, making it main to hang-up research. Evidence suggests that never-ending marijuana use grant permission influences marijuana use disorder (CUD), characterized by removal syndromes, resistance, and resumed use despite adverse belongings. While THC is popular for allure habit-forming potential, CBD exhibits anxiolytic and likely anti-habit-forming possessions. Moreover, cannabinoids influence the dependence process of added essences like opioids and stimulants by either exacerbating reliance or contributing healing benefits for retraction and relapse stop. Advances in understanding the neurobiology of cannabinoid addiction focal point the need for nuanced requirements, healing use, and community health methods. Future research should aim to bridge existing information breaks and determine the long-term impact of cannabinoids in alcohol abuse circumstances.
Cannabinoids, A habit of activity, Marijuana use disorder, THC, CBD, Endocannabinoid structure, Substance abuse, Removal, Relapse, Neurobiology