Combating Pseudomonas aeruginosa Biofilms by Potential Biofilm Inhibitors

Ten potential antibiofilm agents (N-acetylcysteine (NAC), ambroxol, piroxicam, diclofenac sodium, ketoprofen, 4-nitropyrdidine-N-oxide (4NPO), sodium ascorbate, sucralose, xylitol and sorbitol) showed varied activity against preformed biofilms formed by twenty clinical isolates of Pseudomonas aeruginosa as demonstrated by minimum biofilm inhibitory concentration (MBIC). 4NPO was the most active; Diclofenac sodium, ketoprofen, N-acetylcysteine, ambroxol, sodium ascorbate and piroxicam showed moderate activity, while sucralose, xylitol, and sorbitol demonstrated weak activity.