Screening of Thrombolytic Activity of Bougainvillea glabra Leaves Extract by In-Vitro

Investigation with the crude methanolic extract of Bougainvillea glabra carried out to evaluate its possible thrombolysis activity. Myocardial or cerebral infractions are the serious consequences in Atherothrombotic diseases leading to death and the side effects produced by consecutive use of thrombolytic agent like t-PA, Urokinase and streptokinase to treat these diseases has become a global concern. Extraction was carried out using Soxhlet apparatus. The crude methanolic extract was found to have significant thrombolytic activity at a dose of 800μ g/ml with a maximum effect comparable with Streptokinase as a positive control and water as a negative control.