Solid Dispersions-An Approach to Enhance the Dissolution Rate of Clopidogrel Bisulphate

Solid dispersions are one of the techniques to improve the solubility of the poorly soluble drugs. In this technique a poorly soluble drug is dispersed in the highly soluble hydrophilic matrix, two types of polymers are considered as carriers i.e., lactose, dextrose and cornstarch. Solubility is the basic step for formulation of different type of dosage forms. clopidogrel bisulphate is a BCS class II drug having low solubility and high permeability, used as ant platelet drug to inhibit blood clots in coronary artery disease, peripheral vascular disease and cerebrovascular disease. In this research article Clopidogrel bisulphate solubility has been increased by co-grinding method i.e.,one of the solid dispersion technique lactose (1:5,1:10,1:15), dextrose (1:10,1:15) cornstarch:lactose (1:10,1:15) from three different polymers cornstarch: lactose showed 99%solubility than dextrose and lactose. In-vitro dissolution studies were conducted in P^H 6.8 buffer.