Asian Journal of Research in Pharmaceutical Science

The present study aimed to investigate the effect of various solvent (petroleum ether, methanol and aqueous extracts) on the extraction of antimicrobial and antioxidant phenolics from stem bark extract of Decalepishamiltonii. The bark extracts were evaluated to find out photochemical by standard methods. Total content of phenolic compounds was estimated by Folin-Ciocalteau method. The susceptibility of microbial strains against the three extracts was determined using the well diffusion method. Antioxidant activity was assessed by DPPH and ABTS•+ assay. The results revealed that the methanol extract had more Phytochemical and highest phenolic content. The extract was exhibited highest zone of inhibition against tested pathogens and was the most potent scavenger of DPPH and ABTS•+ radicals. This study clearly indicated that the methanol solvent is the most suitable for extraction of antimicrobial and antioxidant phenolics from stem bark of D. hamiltonii and provide a better way to utilize in food and pharmaceutical industry.