Formulation, Characterization and In Vitro Evaluation of Lamivudine Microspheres

Lamivudine is an antiretroviral drug, specifically a nucleoside reverse transcriptase inhibitor. It is used to treat HIV. Retroviruses use the genetic material in the body's cells to produce more viruses which can infect other cells. Adverse effect of Lamivudine headache, fever, chills, and muscle aches, dizziness, nausea, vomiting, insomnia, restlessness, and rash. The main objective of this research work was to prepare hydroxypropyl methyl cellulose microspheres loaded with Lamivudine and in vitro release study. In the present study, emulsification heat stabilization method is used in the preparation microspheres. Microspheres were spherical shape and smooth surface. Infrared spectra showed identical peaks of the drug and polymer. Drug entrapment efficiency was determined by uv-spectrophotometry at 254 nm. In vitro release studies were performed by using shaking flask method about drug was released in 10hrs. It is concluded that hydroxlyproply methylcellulose and microspheres of Lamivudine can be prepared by emulsification heat stabilization in vitro release data is satisfactory.