Asian Journal of Research in Pharmaceutical Science

Five series of benzothiazole moieties were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds BT-02 exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. The analgesic activity of compounds performed by using tail immersion method. in this case, compound BT-02 shows activity at 100 mg/kg dose 46 ± 0.22, 51 ± 0.22, 58 ± 0.43, 48 ± 0.27 at time interval of 30 min, 1 hour, 2 hour, 3 hour respectively compare with the other compounds due to the greater electronic effects.