Asian Journal of Research in Pharmaceutical Science
  • Year: 2018
  • Volume: 8
  • Issue: 3

Evaluation of Anticancer activity of Maytenus emarginata on Ehrlich's Ascites Carcinoma treated mice

1Assistant Professor, Department of Pharmacology, Jyothishmathi College of Pharmacy, JNTUH

2Principal, Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, JNTUH

3Associate Professor, Department of Chemistry, Surabhi Dayakar Rao College of Pharmacy, JNTUH

4Assistant Professor, Dept. of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, JNTUH

5Assistant Professor, Department of Quality Assurance, Jyothishmathi College of Pharmacy, JNTUH

*Corresponding Author E-mail: sallapujitha@gmail.com

Online published on 24 October, 2018.

Abstract

The objective of present study is to explore the anticancer activity of the Ethanolic Extract of the Maytenus emarginata (EEME) in Swiss albino mice against Ehrlich ascites Carcinoma (EAC) cell-line.

The dose of 100 and 200 mg/kg body weight EEME was administeredintra-peritoneally for nine consecutive days. Twenty-four hours of last dose and 18hrs of fasting, the mice were sacrificed and antitumor effect of EEME was assessed by evaluating tumor volume, viable and non-viable tumor cell count, tumor weight and hematological parameters of EAC bearing host.

EEME showed significant decrease in (p<0.01) tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile such as RBC, hemoglobin, WBC and lymphocyte count reverted to normal level in EEME treated mice.

From the result it was showed that the extract has potent dose dependent anticancer activity and that is comparable to that of 5-fluorouracil.

Keywords

Maytenus emarginata, Ehrlich Ascites Carcinoma (EAC), tumor volume, viable cell count, tumor weight