Recent Trends in Development of Gastro-Retentive Floating Drug Delivery System: A Review

The purpose of writing this review on floating drug delivery systems (FDDS) was to assemble the recent literature with special focus on the principal mechanism of floatation to accomplish gastric retention. Drug delivery systems are those that float instantly upon contact with gastric fluids present capable approaches for raising the bioavailability of drugs with absorption windows in stomach or upper small intestine, unbalanced in the intestinal or colonic environment, and show little solubility at high pH values. It is novel drug delivery system maximize efficiency and compliance. The Physiological problems like short gastric residence time and impulsive gastric emptying time were conquer with the use of floating dosage forms which offer opportunity for both local and systemic effect. Gastroretentive systems can remain in the gastric section for several hours for considerably extend residence time of drugs by which improves bioavailability, reduces drug waste, and improves solubility for drugs that are a smaller amount soluble in a high pH surroundings. The present review addresses briefly about the floating drug delivery systems.