*Department of Chemistry, SVS College of Engineering, Coimbatore, India
**Department of Chemistry, Coimbatore Institute of Technology, Coimbatore, India
Online published on 9 November, 2016.
New ruthenium(II) complexes with formulae [RuCl(CO)(PPh3)2((H-Sal-sadtc)] and [RuCl(CO)(PPh3)2(H-Nap-sadtc)] (1 and 2) where, [H-(Sal-sadtc)= Salicylic -S-allyl dithiocarbazate, H-(Nap-sadtc) = 2-hydroxy-1-naphthaldehyde-S-allyldithiocarbazate] have been synthesized and characterized by Elemental analysis, FT-IR, NMR, UV-VIS, ESI mass spectral studies and powder X-ray diffraction(XRD). Both the Schiff base ligands are coordinated to the ruthenium through azomethine nitrogen (C=N) and thiolato sulfur donor atom in the thiolate form. A tentative octahedral geometry is concluded for the new complexes. To explore the potential medicinal values of ruthenium(II) complexes with calf thymus DNA and bovine serum albumin(BSA) have been studied at normal physiological conditions using fluorescence spectral methods, which revealed an intercalative mode of interaction. Further, their enzyme kinetic studies reflect the fact that ruthenium(II) complexes are also effective in catechol oxidase acivity and catalytic(hydrolysis reaction of the 4-nitrophenyl phosphate(4-NPP)). The highest Kcat (T.O.N) value suggested that the selected compounds have displayed higher rate of catalytic efficiency.
Ruthenium, DNA/BSA – Interaction, Catechol and phosphatise
