1Research Scholar, School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India, moumita4n6@gmail.com
2Research Scholar, School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India, pankajtemunkar@gmail.com
3Research Scholar, School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India, pragya.genetics@gmail.com
4Professor, School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India, mitashree.mitra@gmail.com
Dopamine receptor gene plays an important role in central nervous system and helps in the proper functioning of neural circuits in the human brain. Polymorphisms of this gene affect the functioning of brain activities. Association of Dopamine receptor D2 gene (DRD2) polymorphisms with cognitive disorders and alcoholism has been reported in various studies now-a-days. The interest on DRD2 polymorphism is not only limited to psychiatric disorders or alcoholic behaviors or pharmacology but it is also a promising gene for evolutionary genetic studies and studies on genetic variations among populations. The present study is an attempt to understand the extent of genetic variations in four tribal populations by using the allele frequencies, haplotype frequencies and the distribution patterns of the three Taq I polymorphic sites of DRD2 gene. 197 unrelated blood samples were collected with individual informed consent and analysed by using standard protocols. All the three sites were found to be polymorphic among the four studied populations. The allele frequency distribution patterns and sharing of haplotypes in this study suggest genetic proximity among the populations.
Dopamine Receptor Gene, Linkage Disequilibrium, Haplotype, Ancestral Allele, Single Nucleotide Polymorphism, Tribal, Chhattisgarh
