Cotton crop is slow in its initial growth and grown with wide spacing is subjected to severe weed competition during early stage that results in low yield. A wide spectrum of weeds with wider adaptability to extremities of climatic, edaphic and biotic stresses are infesting the cotton fields. High persistence nature of weeds is attributed to their ability of high seed production and seed viabilily. Hand weeding/Hoeing twice is the most commonly adopted method of weed control in cotton. However, complete weed control cannot be achieved by using any single method alone. Herbicidal weed control is a competitive and promising way to control weeds at initial stages of crop growth. Fluchloralin 1.0 kg ha−1 (PPI), Pendimethalin 1.5 kg ha−1 (PRE), Diuron (PRE - 1.125 kg ha−1 and PO-0.75 kg ha−1) were some of the effective herbicides in cotton. Effective weed control and highest seed cotton yield is obtained when herbicides were combined with hand weeding/hoeing than either practice was used alone. Integration of weed management practices not only boost the productivity but also help in the sustainability. Maintaining weed free period upto 60 days after sowing (DAS) is more remunerative and essential to obtain higher yield in cotton.