Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, Bareilly, Uttar Pradesh, India
*Corresponding Author: Akash, Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, Bareilly, Uttar Pradesh, India, Email: anant.akash9@gmail.com
Online published on 12 October, 2021.
Most commonly used α2-adrenoceptor agonist shows adverse cardiovascular effects during anaesthesia. They mainly depress the cardiovascular system by provoking vasoconstriction followed by bradycardia. Although α 2-adrenoceptor antagonist like atipamezole can reverse these effects along with that they also reverse the sedation and nociception. Concomitant administration of peripherally acting α2-adrenoceptor antagonist MK-467 can reverse the adverse cardiovascular effect of α2-adrenoceptor agonists without affecting the sedation and nociception. MK-467 has been successfully used in different animals like dogs, cats, sheep, horses along with different α2-adrenoceptor agonist drugs. This review aims to summarize the effects of MK-467 on sedation, cardiopulmonary system, the minimum alveolar concentration of different inhalant anaesthetics, plasma drug concentration, plasma glucose and insulin in different animals.
α 2-adrenoceptor agonists, Atipamezole, Cardiopulmonary system, MK-467, Vatinoxan hydrochloride
