1Department of Animal Biotechnology, CSCRRM, Madras Veterinary College, Chennai-7, India
2Departmentof Veterinary Clinics, Madras Veterinary College, Chennai-7, India
3Central University Laboratory, TANUVAS, Chennai-51, India
*Corresponding Author: Mangala Gowri A., Department of Animal Biotechnology, CSCRRM, Madras Veterinary College, Chennai-7, India, Email: mangalagowri.a@tanuvas.ac.in
Online published on 15 October, 2019.
Blood cells are responsible for constant maintenance and immune protection of every cell type of the body and this relentless and brutal work requires cells that have the greatest powers of self-renewal and are designated as hematopoietic progenitor cells (HPCs). Peripheral blood stem cells in circulation have become the most common source of hematopoietic stem cells intended for transplantation after minimal manipulation. Homeobox (Hox), sonic hedgehog (SHH), and wingless-type MMTV integration site family (Wnt) are known to modulate the self-renewal and expansion of hematopoietic progenitor/stem cells in humans and mice. Unlike cytokines, Hox, SHH, and Wnt are highly conserved among species from flies to humans, but studies regarding the self-renewal and expansion of the HSC are extremely limited in dogs.
Blood, Canine, Gene expression, Self-renewal
