1Zoology Department Faculty of Science, Alexandria University, Moharram Bey, Alexandria21511, Egypt
2Zoology Department College of Science, King Saud University, Prince Turki First street, P.O. Box 22452, Riyadh11352, Saudi Arabia
*Corresponding Author: Email: kadham_100@yahoo.com
Online published on 22 July, 2021.
Aluminum smelting industry is implicated with documented health risks. This study examined toxic effects of aluminum smelting dust as a real-life chemical hazard instead of single aluminum compounds, which seldom exist in real life.
Adult male rats were gavaged acute (3 consecutive days) and chronic (6 weeks) doses of two dust concentrations (10 and 20 mg kg1). Experimental investigation included toxic metal accumulation and biochemical analysis of blood and liver.
Aluminum and iron were highest in dust and respectively accumulated in brain, liver and kidneys. Anemia, inflammation, liver and kidney damage and oxidative stress were established in view of thrombocytopenia (35%), leukocytosis (41%), lymphocytosis (55%) and alterations in aminotransferases, creatinine, malondialdehyde, superoxide dismutase and catalase. Aluminum facilitation of iron-mediated lipid peroxidation is suggested. These findings drew attention to the magnitude (dose-dependent) and persistence (time-dependent) of aluminum dust as health compromising and are of particular significance to workers in aluminum smelting industries.
Aluminum dust, Bioaccumulation, Hemogram, Oxidative stress, Serum biochemistry
