1Department of Pharmacology, Faculty of Medicine, Cukurova University, Adana, Turkey.
2Department of Pharmacology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
3Department of Pharmacology, Faculty of Pharmacy, Cukurova University, Adana, Turkey.
4Department of Medical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey.
*Corresponding Author: Ozge Ozturk Cimentepe, Department of Pharmacology, Faculty of Medicine, Cukurova University, Adana, Turkey, Email: ozge-ozturk01@hotmail.com
Online Published on 10 May, 2023.
Smooth muscle contraction and enlargement of the prostate are important targets for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia. The effect of Ferula elaeochytris (FE) root extract on tissues that play a role on fertility such as the prostate has not been demonstrated yet. The aim of this study is to investigate the effects of FE extract on isolated rat prostate tissue induced by electrical field stimulation (EFS) in vitro.
In this experimental study, 48 male rats were randomly divided into 6 groups (n = 8). Groups were consisting FE (20 μl), FE + Adenosine triphosphate (ATP; 50 μM), FE + prazosin (0.3 μM), FE + Calcium (Ca2+; 3 mM and 6 mM), FE + suramin (100 μM), FE + phenylephrine and FE + carbachol.
In our study, FE extract inhibited the neurogenic contractions induced by EFS on isolated rat anterior prostate tissue. The presence of suramin and prazosin were not significantly increase the inhibition caused by the FE extract, while Ca2+ and ATP significantly increased the inhibition by the FE extract. (p<0.05). In addition, FE extract significantly inhibited phenylephrine and carbachol contractions (p<0.05).
Electrical field stimulation (EFS), Ferula elaeochytris, Prostate, Smooth muscle
