Potential of oxalate decarboxylase of Pseudomonas sp. OXDC12 in degradation of oxalate content of vegetables

Oxalate is a small dicarboxylic acid that is likely to cause chronic kidney diseases, end stage renal diseases (ESRD) - associated cardiovascular diseases, polycystic kidney diseases and/or poor renal allograft survival. Elevated oxalate levels in the urine are a critical factor for recurrent urolithiasis and progressive nephrocalciniosis. Endogenous metabolism and diet form two major sources of urinary oxalate. Dietary oxalate is mainly contributed by plants and plant products. Vegetarians who take mainly plant based diets tend to have a high oxalate intakethat results in hyperoxaluria and associated chronic kidney diseases. Oxalate decarboxylase (OxDC) has hypothetically been suggested to be used as a potent therapeutic for calcium oxalate (CaOx) urolithiasis and diet induced hyperoxaluria. The present study aims to investigate the potential of OxDC from Pseudomonas sp. OXDC 12 in degradation of oxalate content of vegetables.