1Reader, Department of Oral and Maxillofacial Surgery, Darshan Dental College, Udaipur, Rajasthan, India
2Reader, Department of Oral and Maxillofacial Surgery, Surendera Dental College and Research Institute, Sriganganagar, Rajasthan, India
3Senior Consultant, Oral and Maxillofacial Surgeon, Clove Dental, India
4MDS, Oral Surgeon, Dr Kardwal's Dental & Face Surgery Hospital, Rawatsar, Hanumangarh, Rajasthan, India
*Corresponding Author: Anupam Bansal, Reader, Department of Oral and Maxillofacial Surgery, Darshan Dental College, Udaipur, Rajasthan, India
Online published on 19 August, 2025.
This study was conducted for Comparative Analysis of Local Anaesthesia with 2 Different Concentrations of Adrenaline.
A total of 50 cases were randomly chosen for the extraction of bilateral mandibular teeth. Regardless of the quantity of teeth extracted, inferior alveolar and lingual nerve blocks were provided (with long buccal blocks applied as needed). Unilateral extractions were performed in one session, while the opposite side was addressed during the subsequent visit. All procedures were conducted by a single operator. Patients with any systemic conditions such as hypertension, cardiac issues, or diabetes were excluded from the study. We compared the efficacy of 2% lignocaine with two different concentrations of adrenaline - 1:80000 and 1:200000.
There were 25 cases in Group 1 that were treated with 1:80000 concentration of LA and 25 cases in Group 2 were treated with 1:200000 concentration of LA. The mean duration of LA in group 1 and group 2 was 153.54 min and 121.47 min. The mean VAS score for group 1 and group 2 were 2.21 and 2.46. A notable increase in pulse rate was observed immediately upon the administration of local anesthesia (LA) containing adrenaline at a concentration of 1:80000, which subsequently returned to normal levels gradually over a period of 60 minutes. But when LA with 1:200000 adrenaline concentrations was used, there was no significant rise in the pulse rate.
The current investigation into two variations of 2% lignocaine with differing concentrations revealed that both exhibit equivalent efficacy. Regarding cardiovascular implications, the 1:80000 adrenaline concentration resulted in a notable increase in pulse rate and blood pressure when compared to the alternative drug. For patients with cardiac conditions and the elderly, the 1:200000 adrenaline concentration is advisable, as it demonstrated enhanced cardiac stability. In the treatment of any patient on medication, it is crucial to recognize the possible medical complications and to consistently utilize the least concentrated vasoconstrictor solution that facilitates deep anesthesia over a specified duration. Local anesthetics with a reduced concentration of adrenaline will not undermine the depth and effectiveness of anesthesia and are deemed safe for this demographic of patients.
