Cell surface hydrophobicity plays an important role in increasing virulence property of Candida albicans. It is responsible for adhesion of pathogens to host tissues and medical devices. Antifungal drugs deceases CSH of Candida cells. Bio-chemicals of plant origin modulate CSH, adhesion and relative biofilm formation on C. albicans Present investigation indicated that carvacrol and citral inhibited CSH of C. albicans. The intensity of inhibition was dose dependent., At the concentration of 0.125 μg/ml Carvacrol showed 80.00 % inhibition of CSH, while in case of citral it was 73.34 %. The inhibitory effects of carvacrol and citral on adhesion of polystyrene plate were 54 and 44 % respectively, indicating that carvacrol as more effective than citral.
CSH, Adhesion, Carvacrol, Citral, Candida albicans
