Anti-ulcer activity of silver nanoparticles in Albino rats

The anti-ulcer activity of silver nanoparticles prepared with Butea monosperma (SNBM) was studied in Swiss albino rats. The effects of the SNBM at the doses of 300 and 550 mg/kg per were compared with famotidine (35 mg/kg b.w.). The results revealed substantial protection against ulcers generated by indomethacin and histamine. In addition, SNBM drastically lowered lipid peroxide level and restored glutathione level. In conclusion SNBM demonstrated anti-ulcer activity by enhancing gastric mucosa's antioxidant capacity and minimizing mucosal damage.