Molecular Docking of Lupeol and Viridiflorol, Isolated from Manilkara hexandra Leaf Extracts Against GABA Receptor of Oryzaephilus surinamensis.

Oryzaephilus surinamensis is referred to as saw-toothed grain beetle, which belongs to the order Coleoptera. It is one of the most destructive pests affecting stored grain products, making them unpalatable and unmarketable. Present study investigates insecticidal potential of two natural compounds against O. .surinamensis. namely, Lupeol and Viridiflorol which were isolated from Manilkara hexandra leaf extracts The docking study indicated that both compounds exhibited significant binding affinity toward the GABA receptor, indicating ligand–protein interactions. Key amino acid residues, involved in binding, were identified, suggesting possible inhibitory effects on neurotransmission pathways. These results indicate that Lupeol and viridiflorol possess significant potential as natural insecticide against O. surinamensis. The study also provides molecular-level insights that support the development of plant-based, alternatives for eco-friendly management of stored-grain insect pests.