1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur-482 001, Madhya Pradesh, India
2Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur-482 001, Madhya Pradesh, India
3A.P.R.I., Dr. Rajendra Prasad Central Agricultural University, Pusa-848 125, Bihar, India
*Corresponding Author: Prateek Mishra, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur-482 001, Madhya Pradesh, India. Email: pmprateek1@gmail.com
Online published on 27 July, 2022.
The current study was conducted at the Department of Veterinary Pharmacology and Toxicology to assess the impact of Emblica officinalis on oxidative stress produced by sub-acute enrofloxacin exposure in albino rats.
Albino rats weighing 200–300 gram were given enrofloxacin and Emblica officinalis orally through gavage needle and blood samples were taken via capillary tube on the 28th day of the experiment and analysed using laboratory procedures.
Sub-acute treatment of Enrofloxacin at doses of 5 mg/kg b.wt. and 10 mg/kg b.wt. generated oxidative stress in rats, as evidenced by substantial changes in oxidative parameters and affected liver and kidney functions, as seen by changes in biochemical markers of liver and kidney function. Emblica officinalis aqueous extract (200 mg/kg b. wt.) effectively reduces oxidative stress and changes in hepatic and renal function caused by enrofloxacin.
Albino rats, Emblica officinalis, Enrofloxacin, Oxidative stress
