Bulletin of Pure & Applied Sciences- Chemistry
  • Year: 2010
  • Volume: 29c
  • Issue: 1

In vivo and In vitro hepatoprotective studies of various extracts of Aphnamixis polystatchya

  • Author:
  • M.F. Valan1, R. Venkataraman2, A. John de Britto3
  • Total Page Count: 14
  • Page Number: 19 to 32

1Lecturer, Department of Chemistry, Sri Paramakalyani College, Alwarkuruchi, Thirunelveli

2Reader, Department of Chemistry, Sri Paramakalyani College, Alwarkuruchi, Thirunelveli

3Reader, Department of Biotechnology and Plant Biology, St Xavier’s College (Autonomous), Thirunelveli (TN)

Department of Chemistry, Sakthi Engineering College, Thiruninravur – 602 024, Tamil Nadu, India

Online published on 22 February, 2013.

Abstract

The Alcoholic extract of bark and leaf of Aphanamixis polystachya (Wall) Parker for its anti hepatotoxic activity against Isonizid (INH) and Rifampicin (RIF) induced hepatic damage in rats. The activity was evaluated by using biochemical parameters such as total Bilirubin, total protein, Alkaline phosphatase (ALP), Asiartate Transaminase (AST), Alanine Transaminase (ALT), glutamate transpeptidase (GGTP). The histopathalogical changes of liver sample were compared with respective control. The extract showed remarkable hepatoprotective effect.

Keywords

Aphanamixis polystachya, Hepatoprotective, INH & RIF, Biochemical parameters, Histopathological studies