Bulletin of Pure & Applied Sciences- Chemistry

  • Year: 2010
  • Volume: 29c
  • Issue: 2

Antipyretic and anti-inflammatory properties of the methanolic leaf extract of Vitex doniana sweet (Black plum)

  • Author:
  • Fanna I. Abdulrahman1,, Mustapha A. Tijjani1, Umar K. Sandabe2
  • Total Page Count: 8
  • DOI:
  • Page Number: 153 to 160

1Faculty of Science, Department of Chemistry, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria

2Faculty of Veterinary Medicine, Department of Veterinary Physiology, Pharmacology and Biochemistry, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria

Abstract

Some of the pharmacological effects of the methanolic extracts of Vitex doniana Sweet were studied in experimental animals. Investigations were carried out on Brewer’s yeast induced pyrexia and egg albumen induced edema in rats. The methanol extract concentrate gave a yield of 10.96% w/w with intraperitoneal LD50 of 2068mg/kg at 95% confidence limit. The result of the Pharmacological evaluation showed the methanol extract to possess some efficacy as observed on its effect on pyrexia and anti inflammation. The extract of Vitex doniana exhibited antipyretic activity as it reduced yeast induced high rectal temperature. It also reduced edema induced by egg albumen. Preliminary phytochemical analysis of the extract revealed the presence of flavonoid, terpenes, glycosides, saponins, steroids and tannins. Thus the results of the investigation collaborates the traditional use of the plant in the treatment of fever and rheumatic pains.

Keywords

Vitex doniana, Antipyretic, Anti-inflammatory, Methanol extract