Bulletin of Pure & Applied Sciences- Chemistry
  • Year: 2018
  • Volume: 37c
  • Issue: 1

One pot synthesis of 1-(3-methyl-4H-benzo [1, 4]thiazin-2-yl) ethanone and its antimicrobial properties

1Department of Chemistry, University College, Thiruvananthapuram

2Department of Chemistry, Sree Narayana College, Chempazhanthy, Thiruvananthapuram

*Corresponding Author Minitha R., Department of Chemistry, University College, Thiruvananthapuram, E-mail: minithabalan1@gmail.com

Online published on 28 February, 2018.

Abstract

A novel 1, 4-benzothiazine derivative, 1-(3-methyl-4H-benzo[1, 4]thiazin-2-yl) ethanone (ATPAC) is synthesized from 2-aminothiophenol and acetylacetone and is characterized by elemental analysis, 1H NMR, IR spectroscopy and electronic spectroscopy. Antimicrobial property of the title compound was determined by MIC using E. coli, V. cholerae and C. albicans.

Keywords

1, 4-benzothiazine, ATPAC, Antimicrobial