Interaction of alcohal and exercise on energy metabolic enzymes in the skeletal muscle fibers of male albino rat

Alcohol consumption and exercise training alters the ATPases and creatine phosphokinase activity in the gastro'cnemius and soleus muscles. Alcohol induced oxidative stress is linked to the metabolism of ethanol. Male wistar strain albino rats (3 months as a ‘young’. 18 months as a ‘old’) were divided into four groups, Group I sedentary control(SC); Group II, exercise (ExT) (30 min, speed of 23 m/mln/day/5 days in a week for a period of 8 weeks); Group III, ethanol treated (Et)(20%, absolute ethanol, 2 gm/kg body weight); Group IV. ethanol treated + exercised (ExT+Et)as mentioned above. Mg⁺⁺, Ca⁺⁺, ATPases and Creatine phosphokinase enzyme were assayed in gastrocnemius (GN) and soleus (SOL) muscle fibres. In the present study all ATPase’ activities were increased in the exercised rats, and decreased in the ethanol treated rats. Wheceas, in exercised + ethanol treated rats 35% increase was observed. From this study it is clear that exercise training reduces the toxic effect of ethanol, and increases the ATPase turnover in the muscle tissues. The CPK activity was increased in exercised rats in both skeletal muscle fibers and the same was decreased in ethanol and combination treatment. The study suggests exercise training may be beneficial to young and old age subjects ethanol due to intoxication.