1Post Graduate and Research Department of Biotechnology & Microbiology, National College (Autonomous), Tiruchirappalli, Tamilnadu620001, India
2School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China.
3Department of Zoology, Arignar Anna Government Arts College, Namakkal. Tamilnadu637001, India.
*Corresponding author: Dr. Rajarajan Thatchinamoorthi, Assistant Professor, PG Research Department of Biotechnology & Microbiology, National College (Autonomous), Tiruchirappalli, Tamilnadu620 001, India. E-mail: biorajarajan@gmail.com
Our earlier study demonstrates that the treatment of acrude extract of Luffaacutangula (L.) Roxb. (Family: Cucurbitaceae), a folkloric hypoglycaemic plant widely used in the southern part of India which reduces glucose level in blood under high glucose load, and in STZ-provoked diabetes in rats. This study was carried out to establish the antioxidant effects of crude extracts of L. acutangula (50 and 100 mg/kg) in STZ-provoked diabetic animals. Regular treatment of the fruit extracts of L. acutangula (50 and 100 mg/kg) for 28 days ensued noteworthy decrease in the levels of plasma TBARS, hydroperoxide, and ceruloplasmin and a substantial increase in plasma GSH, vitamins C and a-tocopherol. Based on the findings, L. acutangulais potential antihyperglycemic agents and restored all the antioxidant factors close to normal range. Thus, our outcomes open new prospects for advanced studies, including, a clinically based study to appraise the antidiabetic potential of the herbs.
Luffaacutangula, Streptozotocin, Antioxidant Enzymes, Antidiabetic Effect
