Stochastic shock model for modafinil increases histamine release in the anterior hypothalamus of rats

A single device shock model is studied. The device is subject to same damage process. Under the assumption that as the cumulative damage increases, the probability that any additional damage will cause failure increases. We find sufficient conditions on the shocking process so that the life distribution will be increasing failure rate. Here Modafinil, acetamide is a well known wake promoting drug used for the treatment of narcolepsy. We investigated the effect of Modafinil on the hypothalamic histamine release in the anesthetized rat using in viva microdialysis. Modafinil (150 mg/Kg., i.p) increased histamine release by 150% of the basal release. The intracerebroventricular injection of modafinil (1nmo1) also increased histamine release, however, when modafinil (1nmo1) was injected directly into the tuberomammillary nucleus, a limited region where cell bodies of the histaminergic neurons are located, histamine release was not altered. The application part is fitted with the mathematical model and conclusion gives best result than the medical report.