Studies on Release of Fluconazole from different Water Soluble PEG Ointment formulations

Antifungal ointment is a topical medication designed to treat fungal infections. Antifungal ointments work by exploiting differences between mammalian and fungal cells to kill the fungal microorganism without dangerous effects on the host. In the present study PEG was used for the preparation of different formulation and their viscosity was determined using Brook field Viscometer and diffusion rate was studied by in vitro release through dialysis. Antifungal activity was also determined using agar plate diffusion assay. In water soluble bases Polyethylene Glycols ointment is the only pharmaceutical preparation. In this experiment F2 formulation showed maximum fluconazole release within two hours. In vivo testing method also showed that the F2 formulation has inhibited the growth of fungus. Since in in vivo condition plates were incubation for the 24-48 hours so there is not very much differences in measured inhibition zone diameter.