Swiss-Model : A web-based computational tool for designing of protein structures

The advent and integration of high-throughput ‘-omics’ technologies (e.g. genomics, transcriptomics, proteomics, metabolomics, glycomics and lipidomics) are now providing unique and comprehensive opportunities for global, molecular investigations of parasitic biology. Proteins are the building blocks of the body and with the aim of in order to understanding the deeper insights into the functionality and disease diagnostic of proteins their three dimensional structure is important. Swiss Model is a web-based integrated service dedicated for construction of protein structures by homology modeling using the principle that if two proteins share a high sequence similarity, they are likely to have extremely similar/almost identical similar three-dimensional structures.The purpose of this article was to review recent applications of bioinformatics tools for large-scale investigations of the proteins structure using Swiss Model.