Biochemical investigation on Eugenia jambolana (Jamun) Bark Extract in Arsenic Induced Toxicity in Rats

Arsenic is a naturally occurring element that is present in the environment in both organic and inorganic forms which causes cancer, heart problems and diabetes due of its chronic exposure. It is of major relevance to examine the antioxidant potential of Eugenia jambolana bark extract for oxidative damage stimulated by arsenic in rats. In sodium arsenite treated rats serum aspartate aminotransferase and alanine aminotransferase were uplifted. Lipid peroxidation was increased and downfall in the activity of antioxidant enzymes- GSH and SOD in RBC, liver, kidney and brain in sodium arsenite injected rats. In dose dependent manner the 70% ethanolic extract of E. jambolana bark altered the negative effect of sodium arsenite and bought back the hematological parameters towards near normal. In plant extract treated rats the glucose, total protein, albumin, blood urea nitrogen, creatinine in plasma and AST & ALT level in serum was brought back to near normal. This study proves that E. jambolana have pharmacological properties against arsenic induced toxicity in rats.