Effect Of Valproic Acid On Growth And Different Stress Indicators With Hal5 Gene In Saccharomyces Cerevisiae Strains

Valproic acid (VA) is used as an alternative therapy to lithium or carbamazepine (CBZ) for several psychiatric/bipolar disorders and act as a mood stabilizer. Hal5p; a halotolerant protein kinase gene, which is regulating K+ transport and has been reported to be suppressor of Li+ sensitivity. High expression of this gene can be used to protect the cells from VA stress. The present finding has been explained the growth of different strains of Saccharomyces cerevisiae under VA stress. Furthermore, the content of trehalose, glycogen, glutathione and TBARS increases, which has been due to overcome the stress mechanism of VA in yeast cells.