1Laboratory of Anatomy, Department of Physical Therapy, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki, 3000051, Japan
2Department of Anatomy and Developmental Neurobiology, University of Tokushima Graduate School Institute of Health Biosciences, Tokushima, 7008503, Japan
1Correspondence to: K. Sawada Laboratory of Anatomy Department of Physical Therapy Faculty of Medical and Health Sciences Tsukuba International University Tsuchiura, Ibaraki 300–0051 Japan
The present study examined the development of the axonal torpedoes of the cerebellar Pur-kinje cells in a Cav2.1 channel mutant, rolling mouse Nagoya. Calbindin D-28k immunostain-ing revealed a few torpedoes in both the cerebellar white matter and all three subdivisions of the deep cerebellar nuclei of rolling mice on postnatal day (PD) 21, while there was no difference in either number among the age-matched controls. On PD 120, the number of torpedoes drastically increased in the white matter of rolling mice. Their numbers in the deep cerebel-lar nuclei also increased in rolling mice during PDs 21 to 120 with no change in their distributions. These results suggest that the axonal torpedoes develop progressively with aging in non-specific populations of Purkinje cells in the rolling mouse cerebellum.
Ca2+ channelopathy, Neuropathy, Swelling, Cerebellum, Ataxia
