Metabolic responses in discrete, Mice brain regions like CC, CG, H and CQ during PTZ induced epileptic seizures.

Epilepsy, a neurological disorder with recurrent seizures, involves disruption of different metabolic enzymes and its related metabolites altering the normal processes of metabolism, either during the onset or post epilepsy in the brain. In the present work, it is convincingly, observed that the Mice brain regions such as Corpus callosum (CC), Cingulate gyrus (CG), Hippocampus (H) and Corpora quadrigemina (CQ) shows significant changes in the activities of metabolic enzymes such as AST, ALT, LDH; ATPases like Na⁺, K⁺-ATPase, Mg²⁺-ATPase, Ca²⁺-ATPase along with their metabolites such as Glucose, Pyruvate, Lactate and Glutamate, altering the metabolic integrity during Pentylenetetrazole (PTZ) induced epileptic seizure. We report from the present work that, H and CG are affected completely during epileptic seizure as compared to its control but CC and CQ shows partly altered as far as metabolism in brain is concerned.