Pharmacokinetics of Ivermectin (Ivermic Super^®) following Single Dose Subcutaneous Administration in Cattle Calves

The present study was undertaken to evaluate the pharmacokinetics of Ivermectin (Ivermic super^®) 0.2 mg/kg b.wt in cattle calves. The study was conducted in four cross-bred male cattle calves (1.0–1.5 yrs in age, weighing 110±5 kg). The plasma concentration of ivermectin was determined by HPLC. The decay in plasma concentration of drug was biexponential in cattle calves. The C_max value of 28.18was obtained at T_max of 4.7 days in cattle calves, following SC administration of Ivermic super^®. The elimination half life (Beta HL), volume of distribution (V1_F) and AUC were calculated as19.18 days, 2.64 L.kg¹, 370.15 day.ng/mL in cattle calves, following SC administration of Ivermic super^®. A dosage regimen of 0.2 mg/kg at 14 days interval is recommended in cattle.