Current Trends in Biotechnology and Pharmacy

Drug compatibility and stability with the diluents is important expected therapeutic outcome. The administration of incompatible and unstable antibiotics admixtures is associated with several life threatening clinical situations. For the treatment of peritonitis or peritoneal infection, antibiotics are delivered at the site through peritoneal dialysis solution. Therefore, the investigation of compatibility and stability of antibiotic with peritoneal dialysis is imperative. To address this matter, the present study is aimed to determine the compatibility and stability of ceftriaxone sodium in isotonic and hypertonic peritoneal dialysis solutions. For such purposes, a spectroscopic method was developed and validated for the determination of ceftriaxone sodium in the presence of peritoneal dialysis solutions. Then the compatibility and stability of the antibiotic in both the peritoneal dialysis solutions at 4°C, 25°C and 40°C for 48 h using three concentrations of the drug such as 250 mg/L, 500 mg/L and 1000 mg/L. The aliquots were drawn from the admixtures at regular intervals and analyzed to determine the drug contents using UV spectrophotometry. The results of the study showed that the drug was stable for 10 days at 4°C, 28 h at 25°C and 8 h at 40°C in both the peritoneal dialysis solutions. The drug was found to be following the 1^st order degradation at all the three temperatures. It is concluded from results of the present study that ceftriaxone sodium is compatible and stable with isotonic and hypertonic peritoneal dialysis solutions.