Ganoderma mbrekobenum: A pharmacologically Important Mushroom Naturally Growing in Raisen, India

Ganoderma is well-known medicinal species of mushroom that has been used for many years in the treatment of different diseases which include migraine, headache, hypertension, arthritis, bronchitis, asthma, anorexia, gastritis, haemorrhoids, hypercholesterolemia, nephritis, dysmenorrhea, constipation, hepatitis, leukopenia and cardiovascular disorders. In present study, wild species Ganoderma mbrekobenum was collected from agroclimatic zone of Vindhya plateau (Raisen 23° 2′ 12″ N and 78° 5′ 3″ E), Madhya Pradesh, India in single and same host plant (lemon tree). On the basis of ITS Gene, BLASTN and phylogenetic analysis, the three collected samples were identified as Ganoderma mbrekobenum (MK940286), G. mbrekobenum (KY865253) and G. mbrekobenum (MK940290).

Further, in background of the therapeutic values of Ganoderma, estimation of bioactive compounds was performed by using LC-MS technique on hot water ethanolic extract of one of the identified species, G. mbrekobenum (MK940286) at IIT, Mumbai. This species has shown to be a source of important bioactive compounds such as Olmesartan Medoxomil, Benazeprilat, Isopropamide, Ganodermic acid A, Ramipri Glucuronide, Desmethyldoxepine, Oleamide, Phorbol myristate acetate and Cepharanthine which are in common medicinal use as a remedy for several chronic diseases. Collectively, the study indicates that the extracted compounds from G. mbrekobenum could be a promising molecular mortar for further exploration as an anti-tumour and anti- inflammatory agent.