1Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University, 56000, Cheras, Wilayah Persekutuan, Kuala Lumpur, Malaysia
2Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Sasaram, Bihar, Pincode 821305
3Immunology Unit Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Jalan Serdang, 43400, Serdang, Selangor Darul Ehsan, Malaysia
Uterine fibroids (UFs) are extremely common neoplasm affecting up to 8 out of 10 women during middle or late reproductive years leading to significant morbidity. Some of the serious complications associated with UFs include abortion, abnormal foetal formation, obstructed labour, postpartum haemorrhage in pregnancy and premature deliveries in pregnant women whereas heavy and prolonged menstrual bleeding, pelvic pressure, anaemia, urinary incontinence, constipation and infertility were discovered in non-pregnant women. Hormonal irregulation particularly estrogen hormone followed by genetics, epigenetics, environmental factors, and lately gut microbiota have been associated in the pathogenesis of UFs. The most common indication for UFs is hysterectomy, whereas medications available were less effective in most of the cases. There are various review articles that have been published on UFs in the past decade. However, up to date review that comprehends epidemiology, pathogenesis, physiopathology and classifications of UFs is not available Thus, ourgoal isto explore and scrutinize every aspects with in the topic to help provide absolute understanding on UFs.
Uterine Fibroid, Neoplasm, Estrogen, Pathogenesis, Hysterectomy
