Mupirocin Niosomal Gel with Bee Honey & Curcumin as Nano-Drug Delivery in Wound Healing Applications

Wound healing research is still aiming toward complete regeneration and restoration of the skin’s function and structure with the least amount of scarring. Controlled and targeted medication distribution to wounds is more convenient than systemic administration, which allows for larger drug concentrations to be delivered to the targeted site over time. The nano wound healing gel demonstrated a dependable administration strategy, excellent local tolerability, and superior drug delivery methods, which can promote faster healing. Recently, niosome formulations have been developed to reduce toxicity while increasing accumulation at the target site. Curcuma longa (CU) and honey are effective at inhibiting the growth of wound-associated pathogens and hastening the healing process. The wound healing potential activity of mupirocin-loaded niosomal gel formulated with honey and curcumin, as well as their blends, by ether injection method and investigated for further studies. FTIR and DSC study reveals the compatibility of the drug and other excipients. In the case of post-approval study the parameters evaluated are entrapment efficiency, drug content, pH, viscosity, spreadability, SEM, in-vitro drug release study, release kinetic study, stability study, and in-vivo wound healing study followed by histopathological study. This study aimed to create an excision wound model in albino rats and compare it to a commercially available ointment (Mupicip by Cipla). The blended formulation (Formulation F7) was administered twice daily, and the wound healing effect was determined by the highest percentage of wound contraction, epithelisation period, and histoarchitecture studies. The obtained results concluded that formulation F7 is considered as best formulation and has shown a higher percentage of wound contraction 99.08%. The histological study also confirms that formulation F7 promotes faster wound healing.