1Department of Pharmacology, Yenepoya Pharmacy College & Research Centre, Yenepoya Deemed to be University, Ayush Campus, Naringana, Mangaluru
2Department of Pharmacy Practice, Yenepoya Pharmacy College & Research Centre, Yenepoya Deemed to be University, Ayush Campus, Naringana, Mangaluru
3Pharmacist, Dubai
4Department of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya Deemed to be University, Ayush Campus, Naringana, Mangaluru
5Librarian, Yenepoya Pharmacy College & Research Centre, Yenepoya Deemed to be University, Ayush Campus, Naringana, Mangaluru
Ayurveda is a traditional Indian medicinal system that has been practiced for centuries and is known as the “Mother of All Healing.” According to the World Health Organization, 80% of the world’s population still relies primarily on traditional medicines for their healthcare. The purpose of the study was to evaluate and confirm the CNS activities of Dhanwantaram Kashayam, an ayurvedic formulation, in experimental animal models. It is a decoction of many herbs that is commonly used for labour pain relief and is given at random for several vata disorders. Because there is not much available literature on it, the following study is to confirm the hypothesis. The animal models selected were tests for anti-convulsant activity, anti-anxiety activity, anti-depressant activity, and muscle coordination activity. The study entails that Dhanwantaram Kashayam polyhedral formulation has highly significant (P<0.001) ant anxiety, antidepressant, analgesic, and muscle relaxant properties. In addition to that, it also has a sedative effect. It was concluded that the Dhanwantaram Kashayam at a high dose (0.5 ml/kg) shows anticonvulsant, antidepressant, anti-anxiety, analgesic, and muscle relaxant activity, whereas the low dose (0.25 ml/kg) shows a sedative effect.
Dhanwantaram Kashayam, Anticonvulsant, Antidepressant, Analgesic, Muscle Relaxant
