1Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, 360005, India
2Graduate School of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, 382028, India
*Corresponding author e-mail: jigna.vadalia@gmail.com
Online Published on 05 July, 2024.
Many traditional plants are promising source of antimalarial drugs. Present study is proposed to evaluate in vitro antimalarial effect of selected plant extracts. Methanol extract of nine plants were evaluated for antimalarial activity against Chloroquine-sensitive (MRC-2) and chloroquine-resistant (RKL-9) strains of P. falciparum. Evaluation was carried out by colorimetric quantification of haemazoin inhibition. Results indicated that all the plant extracts showed antimalarial activity in dose dependent manner. Methanol extract of E. hirta, E. thymifolia and B. variegate showed moderate antimalarial activity against MRC-2 and RKL-9 strains. Methanol extract of leaves of B. variegata demonstrated highest activity with lowest IC50 21.85 μg/mL and 26.51 μg/mL against MRC-2 and RKL-9, respectively amongst all extracts. This result potentially justifies the antimalarial use of this plant.
Antimalarial, Haemazoin, Plant extracts, P. falciparum
