1Department of Microbiology and Biochemistry, Faculty of Sciences, Mohamed Boudiaf-M'sila University, M'sila, Algeria
2Laboratory of Biology: Applications in Health and Environment, Faculty of Sciences, University of M'sila, PO Box 166 Ichebilia, 28000, M'sila, Algeria
3Department of Cellular and Molecular Biology, Faculty of Natural Sciences and Life, University of El-Oued, Algeria
4Laboratory of Biodiversity and Application of Biotechnology, Faculty of Natural Sciences and Life, University of El-Oued, Algeria
*Corresponding author: dersamebio@gmail.com
Online published on 4 July, 2024.
Our study aimed to investigate the impact of purslane (P. oleracea) and zinc as a therapeutic approach to physiological and biochemical alterations induced by Alzheimer disease (ALZ) in rats. For this purpose, 18 males albino Wistar rats were randomly divided into 4 groups (n=6); healthy rats (Control), untreated Alzheimer rats (Exp ALZ), Alzheimer rats treated with aqueous purslane extract (APE) and Alzheimer rats treated with purslane extract and zinc (PE-Zn). Various neurological and biological parameters were estimated and brain Histopathology was observed. Results of study showed an alteration in passive avoidance learning (PAL) and a significant increase in AChE activity (P<0.01) and protein, WBC, Monocyte, LYM, platelet and MDA levels and decreasing the GSH levels, GST and SOD activities in Exp ALZ group compared to control. In the other hand, histopatho-logical analysis recorded a deep modification in brain tissues of Alzheimer rats group compared to control. However, the treatment of ALZ rats by APE and zinc ensured a partial amelioration and correction of the previous parameters. We conclude that the use of purslane seems to be the powerful limited of Alzheimer disease development or its complications.
Alzheimer, Purslane, Zinc, HPLC-QTOF-MS, Amyloid B, AChE, Oxidative stress
