Ameliorative potential of aqueous extract of Pterocarpus marsupium Roxb bark on diabetes associated metabolic alterations

In this study, have the effect of oral administration of aqueous extract of the bark of Pterocarpus marsupium Roxb (PM) for a period of 12 weeks on diabetes associated metabolic alterations in normal and streptozotocin (STZ) induced diabetic rats has been studied. The parameters checked are plasma insulin, glycosylated hemoglobin, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), ã-glutamyl transferase (ã GT) and creatine kinase (CK). After administration of PM extracts the levels of glycosylated hemoglobin, total cholesterol, triglycerides, LDL –cholesterol were normalized in diabetic rats. It also reversed the elevated levels of AST, ALT, ALP, ã- GT and CK to near normal levels. The levels of plasma insulin, glycosylated hemoglobin, and liver glycogen were also restored after PM treatment. The results of this study, indicates that PM possesses desirable effect on diabetes associated metabolic alterations in experimentally induced diabetes mellitus.